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Simona Cotesta Selected Research

JDQ443

12/2022JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
1/2022Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

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Simona Cotesta Research Topics

Disease

3Neoplasms (Cancer)
12/2022 - 09/2010
3Sleep Initiation and Maintenance Disorders (Insomnia)
10/2013 - 01/2013
2Bone Diseases (Bone Disease)
11/2015 - 09/2010
2Sleep Wake Disorders
10/2013 - 01/2013
1Pulmonary Arterial Hypertension
01/2023
1Wounds and Injuries (Trauma)
01/2021
1Skin Ulcer
01/2021
1Rheumatoid Arthritis
10/2020
1Obesity
10/2020
1Liver Cirrhosis (Hepatic Cirrhosis)
10/2020
1Ulcerative Colitis
10/2019
1Hypertension (High Blood Pressure)
10/2019
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2018
1Infections
06/2012
1Malaria
06/2012
1Osteolysis
09/2010
1Osteoporosis
09/2010
1Breast Neoplasms (Breast Cancer)
09/2010

Drug/Important Bio-Agent (IBA)

2JDQ443IBA
12/2022 - 01/2022
2G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
10/2020 - 10/2019
2Succinic Acid (Succinate)IBA
10/2020 - 10/2019
2MineralsIBA
11/2015 - 09/2010
2farnesyl pyrophosphate (farnesyl diphosphate)IBA
11/2015 - 09/2010
2Diphosphonates (Bisphosphonates)IBA
11/2015 - 09/2010
2Orexin ReceptorsIBA
10/2013 - 01/2013
2almorexantIBA
10/2013 - 01/2013
2suvorexantIBA
10/2013 - 01/2013
2Orexin Receptor AntagonistsIBA
10/2013 - 01/2013
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2023
1pyrazoleIBA
12/2022
1ReninIBA
10/2019
1Retinaldehyde (Retinal)IBA
10/2019
1Oncogene Proteins (Oncogene Protein)IBA
01/2018
1MK-6096IBA
01/2013
1N- ((1- ((5- (4- fluorophenyl)- 2- methyl- 4- thiazolyl)carbonyl)- 2- piperidinyl)methyl)- 4- benzofurancarboxamideIBA
01/2013
1Antimalarials (Antimalarial Agents)IBA
06/2012
1Zoledronic Acid (Zometa)FDA Link
09/2010

Therapy/Procedure

1Therapeutics
01/2021